in recent times, substantial development is created in delineating the mechanisms by which inflammatory cytokines and their receptors aid tissue repair and regeneration. This mini critique focuses on emerging literature around the part in the cytokine macrophage migration inhibitory component (MIF) and its mobile membrane receptor CD74, in defending versus injury and selling therapeutic in numerous elements of the body.
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that is certainly, stimulation of CD74 with exogenous MIF may result in an excessive inflammatory condition, as MIF is effective at stimulating CXCR2 and CXCR4 receptors Besides CD74. CXCR2 and CXCR4 receptors when activated advertise inflow of neutrophils and lymphocytes, respectively (63, sixty four).
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